Pavel is founder and managing partner of Advance Healthcare Management Institute, a company specialized in executive education and consulting in health care management. He is also member of the National Economic Council of the Czech government and lectures at the Charles University in Prague.

Until 2009 Pavel served as a deputy state secretary of health of the Czech Republic, responsible for health insurance and reimbursement of drugs and medical devices. At the same time Pavel was a non-executive member of the board of the General Health Insurance Fund of the Czech Republic.

In 2005-2010 Pavel was member of the European Health Innovation Leadership Network, a high level forum of payers, regulators and producers in the area of pharmaceutical policy.

In 1998–2002 Pavel worked as a consultant for the Prague office of McKinsey & Company.  At McKinsey he advised clients in health care, insurance and banking in several European countries.

Pavel has MD from the Charles University in Prague and Master of Science degree in health policy and management from the Harvard School of Public Health.