Technology & Innovation

Reopening the ethical debate on genetic engineering

January 13, 2016

Global

The ethical implications of CRISPR

January 13, 2016

Global
Our Editors

The Economist Intelligence Unit

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A new technique has made it possible and cheap to edit the human germline. Society needs to discuss the ethical implications sooner rather than later

Genetic engineering has been around for over four decades, and so too has the debate around the ethical implications of modifying an organism’s DNA.

The technology is used in agriculture to produce crops that are resistant to pests, disease and adverse climate, in an effort to increase, economically, food supplies for an ever-growing world population. This is despite criticism from environmental and other groups who argue that the risks of genetic engineering, including the potential for harmful health effects on humans and animals due to unintended gene alterations, don’t justify the benefits.

This ethical debate has been reignited by a new technique called CRISPR editing that promises to make genetic engineering cheaper, easier and incredibly fast. Developed only in 2013, the technique is considered the “biggest game changer to hit biology.”

It exploits a defence mechanism bacterial cells use to fight viral infections - namely clustered regularly interspaced short palindromic repeats, or CRISPR. Evidence is beginning to emerge, for example, that CRISPR editing could help cure certain diseases.  In 2014, Massachusetts Institute of Technology researchers published, in Nature Biotechnology, the first research showing that, in animal models of a human liver disorder, CRISPR can reverse the disease’s symptoms, by correcting a gene mutation. Meanwhile, a team led by Scot Wolfe, from the University of Massachusetts Medical School, is using CRISPR in the hope of clipping out the DNA of the HIV virus from the human genome.

The reason why CRISPR has reopened the ethical debate around genetic modification is that it is especially effective for modifying DNA in eggs, sperm and embryos. That means the changes could be passed on to successive generations. This means it allows changes to be passed to future generations. Known as germline editing, this has the alarming, but real, potential to permanently alter the human genome, in unexpected and unforeseeable ways.

Adding to these concerns is the fact that CRISPR can be used by virtually anyone who has access to a laboratory and sufficient knowledge, which makes it difficult to monitor what’s going on, and possible for people without the right level of expertise to use the technique.

In April, Chinese researchers of Sun Yat-sen University, Guangzhou, reported using CRISPR to carry out the world’s first germline modification. The team used non-viable embryos, which cannot result in a live birth. But the research, published in Protein & Cell, didn’t fail to spark a heated debate.

Ethical, safety and other issues surrounding CRISPR are being taken seriously. Hundreds of scientists, ethicists and other groups gathered in December at the International Summit on Human Gene Editing, in Washington D.C., to discuss the challenges ahead. Following the summit, they issued a statement saying: “it would be irresponsible to proceed with any clinical use of germline editing unless and until (i) the relevant safety and efficacy issues have been resolved, based on appropriate understanding and balancing of risks, potential benefits and alternatives, and (ii) there is broad societal consensus about the appropriateness of the proposed application.”

As that second clause reveals, there is only so much that scientists can decide on their own, despite their expertise. Society as a whole needs to figure out in which circumstances, if any, editing the human germline is permissible, because the technological barriers to doing so have all but disappeared.

When do you think it might be appropriate to make permanent edits to the human germline? And how can the societal debate be encouraged? Share your thoughts over on the , sponsored by Dassault Systemes. 

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